Luxury hotels in Rochester

Hey! When I travel I love to stay at luxurious hotels - especially the kind of places that offer over the top extras and really spoil their guests with great service, nice spas, awesome restaurants and beautiful views. What more can you want? To save some time, I've put together this list of my favourite 5-star hotels and resorts in Rochester. I hope you will like it!

• 1 Comfort Inn & Suites Rochester South Mayo Clinic Rochester, United States

  

  Hotel. Set within 13 km of Plummer Building and 13 km of Mayo Civic Center, Comfort Inn & Suites Rochester South Mayo Clinic provides rooms in Rochester. Featuring a fitness centre, the 5-star hotel has air-conditioned rooms with free WiFi, each with a private bathroom. The hotel offers an indoor pool, hot tub and free shuttle service. At the hotel, the rooms are equipped with a desk. All guest rooms will provide guests with a fridge. A continental breakfast is available at Comfort Inn & Suites Rochester South Mayo Clinic. Guests will find a 24-hour front desk, a shared lounge and a business centre at the property. Rochester International Airport is a few steps from the property. Show full description Guest review score 8.5, rooms from around $89.

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• 2 Econo Lodge Mayo Clinic Area Rochester, United States

  

  Lodge. The 100 percent non-smoking Econo Lodge® hotel is located near the Apache Mall, the Mayo Clinic, Mayo Civic Center, Olmsted County Fairgrounds and Graham Arena Complex, a hockey and event center. The Rochester International Airport is six miles from this hotel. The Mayo Clinic offers an art and architecture tour. Guests can also visit the Gilded Star Gallery, Rochester Art Center and Taylor-Gebler Gallery for a taste of local creativity. There are over 60 miles of paved bike trails winding throughout the city of Rochester. The hotel provides shuttle service to the Mayo Clinic and to St. Mary's Hospital Monday through Friday. This hotel offers many amenities, including free wireless high-speed Internet access, free continental breakfast, free 24-hour coffee service, free local and long distance calling in the continental U.S. Business travelers can appreciate high-speed wireless connections and access to copy and fax services. All guest rooms include refrigerators, microwaves, hair dryers and cable television with HBO. Coin-operated laundry facilities are provided for guest convenience. The hotel has plenty of free parking. Show full description Guest review score 8.5, rooms from around $88.

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I try my best to keep this guide up to date and I last refreshed it in August 2026. Did I miss a luxury hotel that should be on this list? Send me an email and let me know!